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When we are stressed our hypothalamus release hormones that travel through the bloodstream to the pituitary gland, which in turn secretes other hormones and activates the adrenal gland, which releases the stress hormone, cortisol. Ashwagandha enhances the body’s activity to resist a stressor. It exerts a normalizing influence on the body, neither over-stimulating nor inhibiting normal body function. Ashwagandha’s is also known to be a powerful antioxidant
Extracts of ashwagandha produce GABA-like activity, which may account for the herb’s anti- anxiety effects. GABA (Gamma Amino-butyric acid) is an inhibitory neurotransmitter in the brain. Its function is to decrease neuronal activity and inhibit nerve cells from over-firing. This action produces a calming effect. Excessive neuronal activity can lead to restlessness and sleeplessness, but GABA inhibits the number of nerve cells that fire in the brain, and helps to induce sleep, uplift mood, and reduce anxiety. There is emerging evidence suggesting a role of ashwagandha in suppressing stress-induced increase of dopamine receptors in the corpus striatum of the brain. It is also claimed to reduce stress-induced increases of plasma corticosterone, blood urea nitrogen, and blood lactic acid. Overall, ashwagandha helps the body in coping with stress by restoring hypothalamic and peripheral receptor sensitivity to the effects of cortisol and other adrenal hormones.